A workbench
for rigorous science.
The MegaBrain Science app runs analyses, searches databases, and traces every step from data wrangling to publication — so you can spend your time on science.
Compute runs on your machine · macOS & Linux
See how it compares to Claude Science, Google Co-Scientist & more →
PubMed retrieval complete. Eight benchmark papers resolved and verified against title and first author; four supplied PMIDs were corrected, two off-topic hits omitted.
An app that does the science,
right where your data lives.
Runs analyses locally
The heavy compute happens on your machine — a live kernel the agent shares. Load a dataset, iterate on it, and never wait on a round-trip or hand your data to a server.
Searches the literature
Query PubMed, OpenAlex, and arXiv from inside the workbench. The agent resolves DOIs, verifies against title and first author, and drops off-topic hits.
Traces every step
From data wrangling to publication, each result traces to the exact code, data hash, and environment — a reproducible record you can hand to a reviewer.
Checks its own work
An independent Reviewer re-derives your headline result in a clean kernel and returns a verdict — Verified, Inconclusive, or Refuted — before you trust it.
The compute happens on your machine.
MegaBrain Science is a desktop app, not a browser tab. The kernel, your files, and the analysis all run locally — so proprietary datasets, unpublished results, and regulated data never leave your hardware. The agent's reasoning runs in the cloud via the MegaBrain Gateway; your data stays put.
- ✓Zero round-trip latency per cell
- ✓No dataset bytes leave your machine
- ✓Bring your own data sources and secrets
- ✓Optional cloud runtime for sharing & long jobs
From download to publication
Download the app
Native builds for Apple Silicon, Intel Macs, and Linux. Install once — the compute runtime ships inside.
Point it at your data
Open a project on files that live on your disk. Nothing uploads; the kernel reads them in place.
Do the science
The agent runs code, searches databases, and drafts the write-up — while the Reviewer verifies each result.
Pre-configured skills, 60+ databases, native renderers
Curated skills and connectors per domain, literature and database search with citations the reviewer verifies, and scientific artifacts rendered in their native form — all on the MegaBrain Gateway.
Native scientific renderers
Inspect 3D protein structures, genome-browser tracks, chemical structures, sequence alignments, and PDFs in their native form.
Persistent Python & R kernels
Variables, dataframes, and loaded models stay in memory across analyses — in whichever language your field uses.
Scales to HPC & GPUs
Attach a kernel over SSH to a Linux box or HPC login node, submit batch jobs, and burst from one GPU to hundreds on demand.
Draft manuscripts in place
Write up results next to the analysis with rendered Markdown and LaTeX — every figure linked to the code that made it.
Domains
Databases
Spend your time on science, not on wrangling.
Download MegaBrain Science and run your first verified analysis in minutes — on your own machine.